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Flupirtine Maleate is a nonopioid centrally-acting analgesic agent with muscle relaxant and neuro protective properties. It appears to work by suppressing pain perception transmission to the brain and spinal cord through stimulation of descending monoaminergic pathways. The drug appears to work by affecting noradrenaline. Flupirtine does not reduce inflammation or fever. The drug works best for pain associated with noninflammatory conditions. In addition to alleviating pain, Flupirtine relaxes muscles through GABA-ergic mechanisms.